I think the best way to look at this question is to first pick a hot job market. A job market (industry) is hot if the companies are having a hard time finding talent for it or its an up and coming type of job (ex: drone pilots). Then you must look at what existing sites there are that serve that market.
If there are only a few sites with no clear leader that is a market you can make money in. Then you can take that market and apply a location to it.
Location + growing industry = job board success.
I’m about to launch a tech job board for a certain state that has no rival. I think its an underserved niche that will slowly make money. And since I’m in it for the long term I have no doubts that it will one day (1-2 yrs) add $1,000/mo to my pockets. And thats only doing it a few hours per week. I’ll use google and facebook ads to sell it to employers and seekers.
In my experience the tougher it is for a recruiter to find a candidate the more likley they are to try a new job board. And as a recruiter myself (yes I’m recruiting for a small tech company) I know that job boards are the ONLY way I can get candidates to apply to our jobs.
Job boards do it better!